Pengembangan Sediaan Gel Antijerawat Kombinasi Ekstrak Herba Meniran (Phylanthus niruri L) dan Ekstrak Daun Sirsak (Annoni muricata L)
نویسندگان
چکیده
Jerawat (Acne vulgaris) merupakan penyakit inflamasi kronik yang terjadi pada unit pilosebaseus. Infeksi dapat disebabkan oleh Propionibacterium acne dan Staphylococcus aureus. Daun sirsak Herba meniran diketahui menghambat pertumbuhan jerawat mampu membunuh bakteri. Penelitian ini bertujuan untuk mengetahui efektivitas sediaan gel kombinasi kedua ekstrak dalam bakteri penyebab (Propionibacterium aureus), melakukan analisa parameter fisik, kimia stabilitas suhu waktu penyimpanan, serta uji iritasi akut dermal terhadap kelinci. Masing-masing dilakukan aktivitas antibakteri dengan metode difusi cakram konsentrasi 50%; 25%; 12,5%; 6,25%; 3,0%; 1,5%; 0,75%, kontrol positif (klindamisin) negatif (DMSO). Selanjutnya pengukuran zona hambat penetapan minimum dari ekstrak. Kombinasi diformulasi eksipien Na-CMC, Gliserin, Propilenglikol, Phenoxyetanol, Aquadest. Uji menggunakan mediklin. Evaluasi meliputi mikrobiologi. Hasil penelitian menunjukkan bahwa herba daun memiliki P. S. aureus 4,5% 3,0% termasuk kategori kuat. Formula memenuhi fisik stabil 4oC, 27oC, 40oC penyimpanan selama 12 minggu. indeks primer diperoleh sebesar 0,40 (kategori respon sangat ringan).
منابع مشابه
ANTIOXIDANT ACTIVITY AND ANTICARCINOGENIC PROPERTIES OF COMBINATION EXTRACT OF SOURSOP (ANNONA MURICATA LINN) AND PEARL GRASS (HEDYOTIS CORYMBOSA (L.) LAM.) (Aktiviti Antioksidan dan Antikarsinogenik daripada Ekstrak Campuran Durian Belanda (Annona Muricata Linn) dan Rumput Mutiara (Hedyotis Corymbosa (L.) Lam.)
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ژورنال
عنوان ژورنال: Jurnal Sosial dan Sains
سال: 2021
ISSN: ['2774-7018', '2774-700X']
DOI: https://doi.org/10.59188/jurnalsosains.v1i11.250